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METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression.
Xia P, Zhang H, Lu H, Xu K, Jiang X, Jiang Y, Gongye X, Chen Z, Liu J, Chen X, Ma W, Zhang Z, Yuan Y. Xia P, et al. Cancer Commun (Lond). 2023 Mar;43(3):338-364. doi: 10.1002/cac2.12403. Epub 2023 Jan 5. Cancer Commun (Lond). 2023. PMID: 36602428 Free PMC article.
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most prevalent cancers in the world, with a high likelihood of metastasis and a dismal prognosis. ...Mechanistically, upregulation of METTL5 promoted c-Myc stability and thus activated its downstream glycolyti …
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most prevalent cancers in the world, with a high likelihood of metast …
NOP2-mediated m5C Modification of c-Myc in an EIF3A-Dependent Manner to Reprogram Glucose Metabolism and Promote Hepatocellular Carcinoma Progression.
Zhang H, Zhai X, Liu Y, Xia Z, Xia T, Du G, Zhou H, Franziska Strohmer D, Bazhin AV, Li Z, Wang X, Jin B, Guo D. Zhang H, et al. Research (Wash D C). 2023 Jun 30;6:0184. doi: 10.34133/research.0184. eCollection 2023. Research (Wash D C). 2023. PMID: 37398932 Free PMC article.
Mitochondrial dysfunction and glycolysis activation are improtant hallmarks of hepatocellular carcinoma (HCC). NOP2 is an S-adenosyl-L-methionine-dependent methyltransferase that regulates the cell cycle and proliferation activities. ...In addition, NOP2 was found t …
Mitochondrial dysfunction and glycolysis activation are improtant hallmarks of hepatocellular carcinoma (HCC). NOP2 is an S-ad …
Daidzin inhibits hepatocellular carcinoma survival by interfering with the glycolytic/gluconeogenic pathway through downregulation of TPI1.
Li L, Xu H, Qu L, Xu K, Liu X. Li L, et al. Biofactors. 2022 Jul;48(4):883-896. doi: 10.1002/biof.1826. Epub 2022 Feb 3. Biofactors. 2022. PMID: 35118741
This study investigates the therapeutic effect of DDZ on hepatocellular carcinoma cells and elucidates the possible mechanisms of action. ...This study shows that DDZ interfered with the survival and migration of hepatocellular carcinoma cells, likely …
This study investigates the therapeutic effect of DDZ on hepatocellular carcinoma cells and elucidates the possible mechanisms …
An aging-related gene signature to predict the prognosis of hepatocellular carcinoma.
Fang Y, Yang W, Wu L, Yao L, Cao X, Chen H. Fang Y, et al. Medicine (Baltimore). 2023 Dec 22;102(51):e36715. doi: 10.1097/MD.0000000000036715. Medicine (Baltimore). 2023. PMID: 38134103 Free PMC article.
Aging increases the susceptibility of various diseases, including hepatocellular carcinoma (HCC). This study aimed to establish an aging-related prognostic model for HCC and to investigate the role of aging-related genes in HCC progression. ...An aging-related risk …
Aging increases the susceptibility of various diseases, including hepatocellular carcinoma (HCC). This study aimed to establis …
Triosephosphate isomerase 1 suppresses growth, migration and invasion of hepatocellular carcinoma cells.
Jiang H, Ma N, Shang Y, Zhou W, Chen T, Guan D, Li J, Wang J, Zhang E, Feng Y, Yin F, Yuan Y, Fang Y, Qiu L, Xie D, Wei D. Jiang H, et al. Biochem Biophys Res Commun. 2017 Jan 22;482(4):1048-1053. doi: 10.1016/j.bbrc.2016.11.156. Epub 2016 Nov 28. Biochem Biophys Res Commun. 2017. PMID: 27908734
Forced expression of TPI1 in HCC cells inhibited cell growth, migration, and invasion in vitro. Consistently, knockdown of TPI1 by shRNA promoted cell growth, migration and invasion. Moreover, overexpression of TPI1 led to slowed tumor growth and decreased tu …
Forced expression of TPI1 in HCC cells inhibited cell growth, migration, and invasion in vitro. Consistently, knockdown of TPI1 …
8DEstablishment and validation of a hypoxia-related signature predicting prognosis in hepatocellular carcinoma.
Cai C, Yang L, Zhou K. Cai C, et al. BMC Gastroenterol. 2021 Dec 12;21(1):463. doi: 10.1186/s12876-021-02057-0. BMC Gastroenterol. 2021. PMID: 34895169 Free PMC article.
BACKGROUND: Hypoxia plays a crucial role in immunotherapy of hepatocellular carcinoma (HCC) by changing the tumor microenvironment. ...We attempt to construct a hypoxia model to predict the prognosis in HCC. RESULTS: We screened out 3 hypoxia genes (ENO1, UGP2, T …
BACKGROUND: Hypoxia plays a crucial role in immunotherapy of hepatocellular carcinoma (HCC) by changing the tumor microenviron …
A hypoxia-linked gene signature for prognosis prediction and evaluating the immune microenvironment in patients with hepatocellular carcinoma.
Wang J, Li Y, Zhang C, Chen X, Zhu L, Luo T. Wang J, et al. Transl Cancer Res. 2021 Sep;10(9):3979-3992. doi: 10.21037/tcr-21-741. Transl Cancer Res. 2021. PMID: 35116696 Free PMC article.
BACKGROUND: Previous research indicates that hypoxia critically affects the initiation and progression of hepatocellular carcinoma (HCC). Nevertheless, the molecular mechanisms responsible for HCC development are poorly understood. ...The estimation power of the pre …
BACKGROUND: Previous research indicates that hypoxia critically affects the initiation and progression of hepatocellular carcinoma …
TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis.
Liu BHM, Tey SK, Mao X, Ma APY, Yeung CLS, Wong SWK, Ng TH, Xu Y, Yao Y, Fung EYM, Tan KV, Khong PL, Ho DW, Ng IO, Tang AHN, Cai SH, Yun JP, Yam JWP. Liu BHM, et al. J Extracell Vesicles. 2021 Aug;10(10):e12135. doi: 10.1002/jev2.12135. Epub 2021 Aug 11. J Extracell Vesicles. 2021. PMID: 34401050 Free PMC article.
There is an emerging evidence about the role of Rab proteins in the biogenesis of extracellular vesicles (EVs). In hepatocellular carcinoma (HCC), using RNA sequencing comparing expression profiles of adjacent non-tumorous tissues and HCC, Rab20 is identified to be …
There is an emerging evidence about the role of Rab proteins in the biogenesis of extracellular vesicles (EVs). In hepatocellular …
Single-Cell RNA Sequencing Revealed That the Enrichment of TPI1(+) Malignant Hepatocytes Was Linked to HCC Metastasis and Immunosuppressive Microenvironment.
Liang Y, Zhong D, Yang Q, Tang Y, Qin Y, Su Y, Huang X, Shang J. Liang Y, et al. J Hepatocell Carcinoma. 2024 Feb 22;11:373-383. doi: 10.2147/JHC.S453249. eCollection 2024. J Hepatocell Carcinoma. 2024. PMID: 38410699 Free PMC article.
BACKGROUND: Tumor metastasis is the leading cause of high mortality in hepatocellular carcinoma (HCC). The metastasis-related HCC microenvironment is characterized by high heterogeneity. ...The negative correlation between TPI1 expression and CD8(+) T cell in …
BACKGROUND: Tumor metastasis is the leading cause of high mortality in hepatocellular carcinoma (HCC). The metastasis-related …
Glycolysis module activated by hypoxia-inducible factor 1alpha is related to the aggressive phenotype of hepatocellular carcinoma.
Hamaguchi T, Iizuka N, Tsunedomi R, Hamamoto Y, Miyamoto T, Iida M, Tokuhisa Y, Sakamoto K, Takashima M, Tamesa T, Oka M. Hamaguchi T, et al. Int J Oncol. 2008 Oct;33(4):725-31. Int J Oncol. 2008. PMID: 18813785
To elucidate the role of increased glycolysis in the progression of hepatocellular carcinoma (HCC), we investigated the associations between the expression patterns of 14 glycolysis-related genes and clinicopathologic factors in 60 HCCs by using pooled transcriptome …
To elucidate the role of increased glycolysis in the progression of hepatocellular carcinoma (HCC), we investigated the associ …